We are officially in the second half of the 2026-27 NFL season with nine weeks in the books.
Week 10 of the season is upon us and Fanatics Sportsbook already has odds available.
The top matchups for Week 10 include the Patriots vs. Lions, Vikings at Packers, 49ers at Cowboys, and Steelers at Bengals.
We will dive into the point spreads and totals for those games, and all of the NFL Week 10 games below.
NFL Week 10 odds
Here is a look at NFL Week 10 point spreads at Fanatics Sportsbook.
- Commanders (+2.5) at Giants (-2.5)
- Patriots (+3) at Lions (-3)
- Chiefs (-3.5) at Falcons (+3.5)
- Texans (-5) at Browns (+5)
- Vikings (+5) at Packers (-5)
- Dolphins (+2.5) at Colts (-2.5)
- Panthers (+1.5) at Saints (-1.5)
- Bills (-8) at Jets (+8)
- Jaguars (-10.5) at Titans (+10.5)
- Rams (-9.5) at Cardinals (+9.5)
- Seahawks (-3.5) at Raiders (+3.5)
- 49ers (-4) at Cowboys (+4)
- Steelers (+3.5) at Bengals (-3.5)
- Chargers (+5) at Ravens (-5)
Patriots (+3) vs. Lions (-3)
Both the Patriots and Lions are looking like fringe playoff teams. New England is 5-4 and is fresh off a humiliating, 45-27 home loss to the Packers. Detroit is 6-2 and has won four games in a row, but it resides in this historically competitive NFC North—where each team already has six wins or more.
The Lions are 3-4-1 against the spread this season, while New England is 3-5-1 ATS.
This game will be played in Munich, Germany and will kick off at 9:30 a.m. ET.
Vikings (+5) at Packers (-5)
This line opened at Packers -3.5 and has since risen to Packers -5.
The reasoning is because of how futile the Vikings’ offense looked on Monday Night Football against the Bills.
To get an idea of how bad it was: Vikings QB Carson Wentz finished the game with a passer rating of 8.9.
The Packers, on the other hand, just lit up a respectable Patriots defense - hanging 45 points on New England.
Minnesota is 4-4 against the spread this season, while the Packers are 6-3 ATS.
49ers (-4) at Cowboys (+4)
The Cowboys (4-5) have not looked great the past two weeks. They fell to the Cardinals on November 1, 33-30 in overtime, and then barely got by the lowly Colts this past Sunday, 27-23.
San Francisco suffered its only loss of the season right before its bye week as it fell to the Falcons, 29-20, on October 25. The 49ers “got right” this past Sunday by smacking the Raiders, 38-17.
Dallas is 4-5 against the spread so far this season, while the Niners are 5-3 ATS.
Steelers (+3.5) at Bengals (-3.5)
The AFC North is another loaded division, and the Steelers and Bengals are currently the cream of the crop. Pittsburgh (6-2) and Cincy (6-2) have both won four games in a row.
The Steelers won the first matchup this season between these division foes, earning a 30-27 victory.
Pittsburgh is 6-2 against the spread so far this season. The Bengals are 4-4 ATS.
NFL Week 10 totals
Here is a look at Fanatics Sportsbook NFL Week 10 totals for every game on the schedule.
- Commanders at Giants: Over 42.0 (-110)/Under 42.0 (-110)
- Patriots at Lions: Over 51.0 (-110)/Under 51.0 (-110)
- Chiefs at Falcons: Over 45.0 (-110)/Under 45.0 (-110)
- Texans at Browns: Over 39.5 (-110)/Under 39.0 (-110)
- Vikings at Packers: Over 40.5 (-110)/Under 40.5 (-110)
- Dolphins at Colts: Over 40.5 (-110)/Under 40.5 (-110)
- Panthers at Saints: Over 48.0 (-110)/Under 48.0 (-110)
- Bills at Jets: Over 51.0 (-110)/Under 51.0 (-110)
- Jaguars at Titans: Over 46.5 (-110)/Under 46.5 (-110)
- Rams at Cardinals: Over 40.0 (-110)/Under 40.0 (-110)
- Seahawks at Raiders: Over 43.5 (-110)/Under 43.5 (-110)
- 49ers at Cowboys: Over 55.5 (-110)/Under 55.5 (-110)
- Steelers at Bengals: Over 48.5 (-110)/Under 48.5 (-110)
- Chargers at Ravens: Over 38.5 (-110)/Under 38.5 (-110)
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