Preacher will be based on the DC/Vertigo comic book of the same name. It revolves around an ex-preacher named Jesse Custer who becomes possessed by Genesis, a supernatural entity that's the product of both an angel and a demon. With the ability to have anyone follow his commands, thanks to Genesis, Custer begins a cross-country odyssey with his ex-girlfriend and an alcoholic Irish vampire in order to find God.
The original comic, written by Garth Ennis and illustrated by Steve Dillon, is a supremely sacrilegious and violent affair that seems difficult to film as a mainstream pic, even given an R rating, so it'll be interesting to see how much Columbia Pictures will censor, if anything.
While we await some more confirmation, Caruso’s directing skills can be scouted in the critically mauled I Am Number Four, currently in theaters.